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Descriptor English: 11-beta-Hydroxysteroid Dehydrogenase Type 2
Descriptor Spanish: 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
Descriptor 11-beta-hidroxiesteroide deshidrogenasa tipo 2
Scope note: 11-beta-hidroxiesteroide-deshidrogenasa dependiente de NAD, de alta afinidad, que actúa en un solo sentido para catalizar la deshidrogenación del CORTISOL y producir CORTISONA. Se encuentra predominantemente en tejidos donde actúan los mineralocorticoides, como RIÑÓN, COLON, GLÁNDULAS SUDORÍPARAS y PLACENTA. La ausencia de esta enzima produce una forma mortal de hipertensión infantil denominado SÍNDROME DE EXCESO APARENTE DE MINERALOCORTICOIDES.
Descriptor Portuguese: 11-beta-Hidroxiesteroide Desidrogenase Tipo 2
Descriptor French: 11-beta-Hydroxysteroid dehydrogenase type 2
Entry term(s): 11 beta Hydroxysteroid Dehydrogenase Type 2
11 beta-HSD2
11 beta-Hydroxysteroid Dehydrogenase Type 2
11beta Hydroxysteroid Dehydrogenase Type 2
11beta-HSD2
11beta-HSD2 Reductase
11beta-Hydroxysteroid Dehydrogenase Type 2
Tree number(s): D08.811.682.047.436.174.600
D08.811.682.047.820.100.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043209
Scope note: An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Mineralocorticoid Excess Syndrome, Apparent
Registry Number: EC 1.1.1.146
Previous Indexing: Hydroxysteroid Dehydrogenases (1992-2003)
Public MeSH Note: 2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003
History Note: 2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
DeCS ID: 38200
Unique ID: D043209
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/08
11-beta-Hydroxysteroid Dehydrogenase Type 2 - Preferred
Concept UI M0076299
Scope note An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Preferred term 11-beta-Hydroxysteroid Dehydrogenase Type 2
Entry term(s) 11 beta Hydroxysteroid Dehydrogenase Type 2
11 beta-HSD2
11 beta-Hydroxysteroid Dehydrogenase Type 2
11beta Hydroxysteroid Dehydrogenase Type 2
11beta-HSD2
11beta-HSD2 Reductase
11beta-Hydroxysteroid Dehydrogenase Type 2



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